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Esses dados comprovam qual o NERVOCURE cumpre o qual promete, vai atender as suas necessidades e superar suas expectativas.
For cosmetic reasons, patients may conceal the arrays beneath a scarf, hat or a wig. The portable field generator can operate from the mains electricity supply or from a rechargeable battery.
TTFields therapy uses electric fields to disrupt cell division. TTFields therapy does not stimulate or heat tissue and targets dividing cancer cells of a specific size. TTFields therapy takes advantage of the special characteristics and geometrical shape of dividing cells, which make them susceptible to the effects of the alternating electric fields.
Não Deixe a Dor Controlar sua própria Vida: Clique neste link doravante exatamente e descubra tais como o Nervocure Pode vir a ajudar você a retomar o controle da sua própria vida, livre DE dores nervosas.
TTFields are low intensity, intermediate frequency alternating electric fields that act upon rapidly dividing glioma and other cancer cells2,3 especially during metaphase, anaphase and telophase of mitotic cell division. When an alternating electric field is generated across a cancer cell, charged molecules within the cell will move back and forth and dipolar molecules will rotate. At sufficiently high frequencies, the motility of such molecules diminishes. Molecules with a high electrical dipole moment such as tubulin dimers and septins are therefore forced to align with the direction of the alternating electric fields (TTFields) under a uniform field distribution, which is generated in cells during metaphase. This disrupts microtubule spindle formation and septin fibres localization during metaphase, leading to mitotic catastrophe, which may culminate in mitotic cell death.
Optune® is a non-invasive portable device that delivers alternating electric fields to dividing cancer cells. The NovoTAL™ system is a software programme that optimizes transducer array layouts for an individual patient based on head size and tumour location. GBM, glioblastoma multiforme; NCCN, National Comprehensive Cancer Network.
Este tempo do início dos efeitos do NERVOCURE É possibilitado a variar do pessoa para pessoa. Certos relatos indicam alívio inicial da dor em poucos dias, enquanto outros mencionam melhora gradual ao longo do algumas semanas.
TTFields’ unique mechanism of action underscores key points related to its effective administration and nervocure clinical benefit. Unlike chemotherapeutic agents, TTFields are only active while the arrays are affixed to the scalp and the alternating electric fields are generated between the transducer arrays. As a loco-regional and non-invasive targeted therapy, TTFields has the benefit of avoiding systemic adverse events associated with chemotherapy and targeted systemic therapies. The primary treatment-associated adverse event experienced by some patients with TTFields is skin irritation below the arrays, which is predictable and easily manageable in the majority of cases.
Many of the cells, however, will be able to proceed from metaphase to anaphase and telophase. During these phases, the dividing cell assumes an hourglass shape as it begins to split into two distinct daughter cells, causing a non-uniform alternating electric field. This non-uniform field causes polarized cellular components to migrate towards the cleavage furrow of the two daughter cells (an effect called dielectrophoresis) and the dividing cells are unable to divide properly. Overall, the anti-mitotic effect of TTFields may ultimately lead to cell death or to the formation of abnormal dividing cells with an uneven number of chromosomes (Fig. 2).
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Ongoing research suggests that TTFields may also inhibit DNA damage repair, impair cellular migration and invasion4 and upregulate autophagy5. The resulting daughter cells exhibit various forms of cell death including immunogenic cell death, suggesting that combining TTFields with immunotherapies may enhance the body’s own antitumour immunity6.